Afeni Shakur, original Black Panther activist and mother of slain hip-hop legend Tupac, passed away Monday night after paramedics removed the 69-year-old from her Sausalito, Calif., home and rushed her to Marin General Hospital. She was treated for approximately an hour before being pronounced dead at 10:28 p.m. The Marin County sheriff’s office confirmed the death and said the coroner’s office would soon determine the cause.

“She was experiencing some type of physical discomfort,” Marin County Sheriff’s Lt. Doug Pittman said Tuesday morning. “Attempts were made to try to remedy those problems at home, but when they got more severe, it was at that time the family friend called 911 and asked for medical help.”

Responding to a call of “a possible cardiac arrest” at Shakur’s home, paramedics arrived around 9:34 p.m. Monday and immediately performed CPR, reports state. Shakur was in the company of a friend when she began to feel ill.

“At this point, there is nothing to indicate to us that there was any foul play, nothing suspicious about this other than this being sadly a natural event that has occurred,” Pittman added.

Information is still being collected as forensic experts research the scene and question Shakur’s relatives regarding her health history and medical records.

“Sheriff’s Coroner’s office will lead investigation to determine exact cause and manner of Afeni Shakur’s death,” the office tweeted Tuesday afternoon.

“This is a tragic loss to this community,” Pittman said.

She was named Alice Faye Williams after her birth on Jan. 10, 1947, in Lumberton, N.C., and her family eventually moved to New York City in the 1960s. She later took on the name Afeni after being inspired by the Black Panther movement.

Shakur and several other Black Panther activists were arrested in April 1969 and charged with conspiracy to bomb numerous vital city locations.

May 12, 1971, all 21 Panthers were acquitted of all charges and released. She gave birth to Tupac the following month, on June 16, in New York City.

She was the main topic of what many consider to be one of the greatest ever ode songs to a mother when Tupac penned his monumental 1995 classic, “Dear Mama,” in which he paid homage to her for overcoming the many challenges she faced while he came of age.

In the recording, he painfully depicted her crack addiction and other difficulties she faced as a single mother with little moral support. Yet, despite all the negatives, his love and respect for her still remained strong.

“There’s no way I can pay you back/But the plan is to show you that I understand/You are appreciated,” he explained in the recording.

After her son’s 1996 murder, Shakur founded Amaru Entertainment, released some of his rare racks and kept his music alive.

Her Tupac Amaru Shakur Foundation provided poetry and theater camps for local Atlanta youths.

She also oversaw his estate, which reportedly earns approximately $900,000 annually.

Her son’s bio-pic “All Eyez on Me” recently wrapped up filming and is scheduled to be released this November, with Danai Gurira in the lead role. Shakur served as a consultant and executive producer for the project.

In recent months, she was negotiating a divorce settlement from husband, Gust Davis. She is survived by her daughter, Sekyiwa Shakur.

Going home services have not yet been announced.